Rejuran Hand Injection vs. Machine Injection: Which One is Better?

VOS Dermatology’s Recommendation for Maximizing Rejuran Satisfaction

Dry skin is a major culprit behind wrinkles and loss of elasticity. Dehydrated skin can make your complexion look dull and rough, no matter how much moisturizer you apply or how much water you drink. If your usual skincare routine isn’t enough, it may be time for a special solution—skin booster injections that deliver hydration and nutrients deep into the skin.

Among the many types of skin boosters available, Rejuran remains one of the most popular choices. However, concerns about pain, swelling, and treatment methods often arise. Understanding how Rejuran is administered plays a key role in managing these concerns.



Why Is Rejuran Treatment?

Rejuran is a skin booster injection designed to improve overall skin health. Its main ingredient, Polynucleotide (PN), is a purified form of DNA extracted from salmon, known for its powerful skin regeneration properties. By stimulating collagen production from within, Rejuran strengthens the skin barrier, enhances elasticity, and restores a youthful appearance. It also helps with hydration, fine lines, and skin texture improvement.


Rejuran offers multiple formulations tailored to different skin concerns:

  • Rejuran Healer – Ideal for overall skin rejuvenation and fine line reduction.
  • Rejuran I – Specially formulated for delicate, thin skin around the eyes.
  • Rejuran HB+ – A blend of Rejuran Healer with hyaluronic acid for enhanced hydration.

With the right approach, Rejuran can help achieve naturally healthier and more radiant skin.

Rejuran Embossing?

After receiving a Rejuran treatment, you may notice small bumps on your skin, known as embossing. These raised marks appear because the substance has been injected into the skin, creating temporary swelling. However, this is not considered a side effect. In fact, embossing is a positive sign that Rejuran has been properly delivered into the dermis layer.


Embossing occurs due to Rejuran’s viscosity and is a natural reaction to the treatment. It is most noticeable immediately after the procedure but gradually subsides over time. The presence of embossing can also indicate whether the injection was accurately administered at the right depth, with proper adjustment based on the patient’s skin condition.



No Visible Effects from Rejuran?

Did your Rejuran treatment feel painful but seem ineffective? The reason may be improper injection technique. If the solution is not delivered correctly into the dermis or if there is a loss of product during injection, the expected results may not appear. Rejuran needs to be injected evenly and precisely into the dermis layer to achieve its full benefits.

Another factor that affects the outcome is the injection method. Rejuran can be administered in two ways:


  • Manual Injection (Hand Injection) – Performed by a skilled practitioner for precise control.
  • Machine-Assisted Injection – Uses a device for even distribution.


Each method has its own advantages, and the choice can impact the effectiveness of the treatment.

Hand Injection vs. Machine Injection: Which is Better?

Pain Hand Injection Machine Injection
Drug Loss None Occurs
Procedure Time Long Short
Embossing More Less
Treatment Area Localized and Precise Across the Entire Face

Derma Shine PRO, the most representative mechanical injection treatment tool


Machine injections use 9 needles simultaneously to administer Rejuran. These needles make contact with the skin’s surface, following the natural curves of the face. However, since our faces are not flat but curved, there may be areas where the needles don’t fit perfectly between the skin and the dermis. This can make it difficult to focus the treatment on specific areas, and some product loss may occur as a result.


For optimal results, hand injection is recommended. With hand injection, the practitioner can precisely control the injection, ensuring that the product is evenly distributed into the skin and creating a more noticeable embossing effect. This method allows for better customization based on the skin thickness, density, and type, adjusting the depth and area of injection to suit the individual.

When it comes to detailed procedures, such as treating sensitive areas like the eyes and nose, hand injection is the only method capable of delivering precise results.



Hand Injection Expert at VOS Dermatology

From the practitioner's perspective, machine injections are certainly more convenient. Hand injections require meticulous attention, as each injection is carefully placed, which takes more time and effort. However, at VOS Dermatology, our approach to administering Rejuran is not about convenience; it's about delivering the most accurate and effective results.


For Rejuran to work effectively, it must be injected precisely into the dermis. Preventing drug loss and ensuring the formation of embossing after treatment are crucial indicators of a successful procedure. If you're looking for a meticulous treatment, it's essential to choose a practitioner with extensive experience in hand injections. The skill and precision of the doctor play a significant role in increasing satisfaction with Rejuran. That's why you should trust the hand injection experts at VOS Dermatology, with years of experience and countless successful treatments!


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